B-cell activating factor detected on both naïve and memory B cells in bullous pemphigoid
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چکیده
منابع مشابه
Gelatinase B–deficient Mice Are Resistant to Experimental Bullous Pemphigoid
Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterized by deposition of autoantibodies at the basement membrane zone. In an experimental BP model in mice, the subepidermal blistering is mediated by antibodies directed against the hemidesmosomal protein BP180 (collagen XVII, BPAG2), and depends on complement activation and neutrophil infiltration. Gelatinase B is ...
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Background B cell activating factor (BAFF) is a member of the tumor necrosis factor superfamily and an important regulator of peripheral B cell survival, maturation and immunoglobulin class-switch recombination. Many studies suggest that BAFF might be a new mediating mechanism in foodrelated inflammation. Higher levels in non-atopic compared with atopic patients, and no correlation between BAFF...
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With the goal to design effective HIV vaccines, intensive studies focused on broadly neutralizing antibodies, which arise in a fraction of HIV-infected people. Apart from identifying new vulnerability sites in the viral envelope proteins, these studies have shown that a fraction of these antibodies are produced by self/poly-reactive B-cells. These findings prompted us to revisit the B-cell diff...
متن کاملBullous pemphigoid
Disease summary: Bullous Pemphigoid is an acquired, chronic, blistering autoimmune subepidermal bullous disease in which autoantibodies are directed against component of basement membrane zone of the skin [1]. It is characterized by formation of cutaneous bullae on the skin and mucous membrane. The pathogenesis involves migration of inflammatory cells into subepithilial tissues due to activatio...
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2014
ISSN: 0906-6705
DOI: 10.1111/exd.12421